Amorphous Solid Dispersions

Theory and Practice

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Science & Nature, Technology, Engineering, Chemical & Biochemical
Cover of the book Amorphous Solid Dispersions by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781493915989
Publisher: Springer New York Publication: November 21, 2014
Imprint: Springer Language: English
Author:
ISBN: 9781493915989
Publisher: Springer New York
Publication: November 21, 2014
Imprint: Springer
Language: English

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems.

Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems.

Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

More books from Springer New York

Cover of the book Food Freezing and Thawing Calculations by
Cover of the book Enrico Fermi by
Cover of the book Smart Materials-Based Actuators at the Micro/Nano-Scale by
Cover of the book Hand Function by
Cover of the book 3D Video Coding for Embedded Devices by
Cover of the book The Psychology of Social Status by
Cover of the book Trauma Informatics by
Cover of the book Beat the Crisis: 33 Quick Solutions for Your Company by
Cover of the book Surgical Approaches to the Spine by
Cover of the book Oxygen Transport to Tissue XXXIII by
Cover of the book The Challenge of CMC Regulatory Compliance for Biopharmaceuticals by
Cover of the book Biogeochemistry of a Forested Ecosystem by
Cover of the book Fundamental Aspects of Plasma Chemical Physics by
Cover of the book Clusters, Orders, and Trees: Methods and Applications by
Cover of the book Handbook of Operations Research for Homeland Security by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy