Antibiotic Resistance

Nonfiction, Health & Well Being, Medical, Medical Science, Microbiology, Pharmacology
Cover of the book Antibiotic Resistance by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642289514
Publisher: Springer Berlin Heidelberg Publication: October 22, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642289514
Publisher: Springer Berlin Heidelberg
Publication: October 22, 2012
Imprint: Springer
Language: English

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

More books from Springer Berlin Heidelberg

Cover of the book Handbook of Nanomaterials Properties by
Cover of the book Führungsleben by
Cover of the book Visualization and Processing of Tensors and Higher Order Descriptors for Multi-Valued Data by
Cover of the book Scheffer/Schachtschabel Soil Science by
Cover of the book Sampling Designs Dependent on Sample Parameters of Auxiliary Variables by
Cover of the book In Situ Transmission Electron Microscopy Studies of Carbon Nanotube Nucleation Mechanism and Carbon Nanotube-Clamped Metal Atomic Chains by
Cover of the book Human-Centric Decision-Making Models for Social Sciences by
Cover of the book X-Ray Contrast Media by
Cover of the book JIMD Reports, Volume 20 by
Cover of the book Pathology of the Gastro-Intestinal Tract by
Cover of the book Dokumentenlogistik by
Cover of the book Optimal Bundling by
Cover of the book Variable Ordering Structures in Vector Optimization by
Cover of the book Photovoltaic Industrial Systems by
Cover of the book Peripheral Nerve Lesions by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy