Atlas of Histology of the Juvenile Rat

Nonfiction, Health & Well Being, Medical, Specialties, Toxicology
Cover of the book Atlas of Histology of the Juvenile Rat by , Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780128026960
Publisher: Elsevier Science Publication: May 4, 2016
Imprint: Academic Press Language: English
Author:
ISBN: 9780128026960
Publisher: Elsevier Science
Publication: May 4, 2016
Imprint: Academic Press
Language: English

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals.

While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

  • Written and edited by highly experienced, board-certified toxicologic pathologists
  • Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies
  • Detailed figure legends and chapter narratives present the salient features of each organ at each time interval
  • Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification
  • Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents
  • Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals.

While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

More books from Elsevier Science

Cover of the book 5G Physical Layer by
Cover of the book Atlas of the Developing Rat Nervous System by
Cover of the book Side Effects of Drugs Annual by
Cover of the book The Biology of the Laboratory Rabbit by
Cover of the book Multifunction Peripherals for PCs by
Cover of the book Progress in Nuclear Energy by
Cover of the book Audio Electronics by
Cover of the book International Review of Cell and Molecular Biology by
Cover of the book Hair Analysis in Clinical and Forensic Toxicology by
Cover of the book Advances in Marine Biology by
Cover of the book Human Reproductive Biology by
Cover of the book Textile-led Design for the Active Ageing Population by
Cover of the book Lead by
Cover of the book Introduction to Satellite Remote Sensing by
Cover of the book Brain Mapping: The Methods by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy