Bayesian Designs for Phase I-II Clinical Trials

Nonfiction, Health & Well Being, Medical, Reference, Biostatistics, Medical Science, Pharmacology, Science & Nature, Mathematics, Statistics
Cover of the book Bayesian Designs for Phase I-II Clinical Trials by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall, CRC Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Ying Yuan, Hoang Q. Nguyen, Peter F. Thall ISBN: 9781315354224
Publisher: CRC Press Publication: December 19, 2017
Imprint: Chapman and Hall/CRC Language: English
Author: Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
ISBN: 9781315354224
Publisher: CRC Press
Publication: December 19, 2017
Imprint: Chapman and Hall/CRC
Language: English

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.

Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.

Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.

Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.

Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

More books from CRC Press

Cover of the book Biodental Engineering IV by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Weed Physiology by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Health Records in Court by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Fundamentals of Environmental Site Assessment and Remediation by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book New Concepts and Trends of Hybrid Multiple Criteria Decision Making by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Rationalizing Acute Care Services by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Dam Maintenance and Rehabilitation by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Computer-Aided Power Systems Analysis by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Biomolecular Kinetics by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book From Computing to Computational Thinking by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Flow-induced Vibrations: an Engineering Guide by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Diversity in Unity: Perspectives from Psychology and Behavioral Sciences by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Hen Eggs by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Atomic Physics by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
Cover of the book Supersymmetry Beyond Minimality by Ying Yuan, Hoang Q. Nguyen, Peter F. Thall
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy