Bile Acids in Health and Disease

Update on Cholesterol Gallstones and Bile Acid Diarrhoea

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Gastroenterology
Cover of the book Bile Acids in Health and Disease by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789400912496
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9789400912496
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

Bile acids occupy a central position in in the absorption, excretion and metab­ olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage­ ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review posssible approaches to gallstone prevention, and assess recent developments in non-surgical forms oftreatment. Two exciting new therapies that receive particular attention are contact dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. Further sections turn to the absorptive functions of bile acids in health.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Bile acids occupy a central position in in the absorption, excretion and metab­ olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage­ ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review posssible approaches to gallstone prevention, and assess recent developments in non-surgical forms oftreatment. Two exciting new therapies that receive particular attention are contact dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. Further sections turn to the absorptive functions of bile acids in health.

More books from Springer Netherlands

Cover of the book Imaginative Participation by
Cover of the book Entropy-Based Parameter Estimation in Hydrology by
Cover of the book Competitive Information in Small Businesses by
Cover of the book The Structure of Coordination by
Cover of the book Size- and Age-Related Changes in Tree Structure and Function by
Cover of the book Modelling of Environmental Chemical Exposure and Risk by
Cover of the book Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by
Cover of the book Regulation for Chemical Safety in Europe: Analysis, Comment and Criticism by
Cover of the book Philosophical Works of Peter Chaadaev by
Cover of the book Conducting Educational Needs Assessments by
Cover of the book Twelve Lectures on Structural Dynamics by
Cover of the book Nephrotoxicity in the Experimental and Clinical Situation by
Cover of the book Spatial Planning and Urban Development by
Cover of the book Reconsidering Conceptual Change: Issues in Theory and Practice by
Cover of the book Reference, Truth and Conceptual Schemes by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy