Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene

Nonfiction, Computers, Advanced Computing, Artificial Intelligence, Computer Science, General Computing
Cover of the book Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene by Amita Kashyap, D. Bujamma, Naresh Babu M, Springer Singapore
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Amita Kashyap, D. Bujamma, Naresh Babu M ISBN: 9789814585088
Publisher: Springer Singapore Publication: September 8, 2014
Imprint: Springer Language: English
Author: Amita Kashyap, D. Bujamma, Naresh Babu M
ISBN: 9789814585088
Publisher: Springer Singapore
Publication: September 8, 2014
Imprint: Springer
Language: English

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.

This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.

This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

More books from Springer Singapore

Cover of the book Business Sustainability Model for Malaysian Housing Developers by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Successful Transposition of Lesson Study by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Active Cancellation of Probing in Linear Dipole Phased Array by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Curriculum for High Ability Learners by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Collaborative Research Design by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Application of Infrared to Biomedical Sciences by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Advances in Big Data and Cloud Computing by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book World Congress on Medical Physics and Biomedical Engineering 2018 by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Topology Optimization of Compliant Mechanisms by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Production of Materials from Sustainable Biomass Resources by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Promoting Language and STEAM as Human Rights in Education by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Computational Signal Processing and Analysis by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Multi-Objective Optimization by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Handbook of Sustainable Luxury Textiles and Fashion by Amita Kashyap, D. Bujamma, Naresh Babu M
Cover of the book Evolutionary Economic Geography in China by Amita Kashyap, D. Bujamma, Naresh Babu M
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy