Bursting Neurons and Fading Memories

An Alternative Hypothesis of the Pathogenesis of Alzheimer’s Disease

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neurology, Science & Nature, Science, Biological Sciences
Cover of the book Bursting Neurons and Fading Memories by Michael R. D'Andrea, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Michael R. D'Andrea ISBN: 9780128019887
Publisher: Elsevier Science Publication: October 10, 2014
Imprint: Academic Press Language: English
Author: Michael R. D'Andrea
ISBN: 9780128019887
Publisher: Elsevier Science
Publication: October 10, 2014
Imprint: Academic Press
Language: English

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

  • The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology
  • A high-level text on AD pathology, and suggestions for progress in a stagnating field
  • Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed
  • Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues
  • Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

More books from Elsevier Science

Cover of the book Pursuing Information Literacy by Michael R. D'Andrea
Cover of the book Creating Digital Faces for Law Enforcement by Michael R. D'Andrea
Cover of the book Seismic Exploration of Hydrocarbons in Heterogeneous Reservoirs by Michael R. D'Andrea
Cover of the book Foods, Nutrients and Food Ingredients with Authorised EU Health Claims by Michael R. D'Andrea
Cover of the book Reducing Saturated Fats in Foods by Michael R. D'Andrea
Cover of the book Molecular Biology of Protein Folding, Part B by Michael R. D'Andrea
Cover of the book Transportation Security by Michael R. D'Andrea
Cover of the book IP Addressing & Subnetting INC IPV6 by Michael R. D'Andrea
Cover of the book Erectile Dysfunction as a Cardiovascular Impairment by Michael R. D'Andrea
Cover of the book Handbook of Econometrics by Michael R. D'Andrea
Cover of the book Reproductive and Developmental Toxicology by Michael R. D'Andrea
Cover of the book Clinical Biochemistry of Domestic Animals by Michael R. D'Andrea
Cover of the book The Development of Early Childhood Mathematics Education by Michael R. D'Andrea
Cover of the book Ethics in Forensic Science by Michael R. D'Andrea
Cover of the book Forensic Textile Science by Michael R. D'Andrea
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy