c-Myc Function in Neoplasia

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book c-Myc Function in Neoplasia by Linda A. Lee, C.V. Dang, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Linda A. Lee, C.V. Dang ISBN: 9783662226810
Publisher: Springer Berlin Heidelberg Publication: November 21, 2013
Imprint: Springer Language: English
Author: Linda A. Lee, C.V. Dang
ISBN: 9783662226810
Publisher: Springer Berlin Heidelberg
Publication: November 21, 2013
Imprint: Springer
Language: English
  1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib­ A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil­ ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi­ fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis­ match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom­ ic instability and could potentially result in the accumulation of car­ cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto­ oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
  1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib­ A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil­ ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi­ fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis­ match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom­ ic instability and could potentially result in the accumulation of car­ cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto­ oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.

More books from Springer Berlin Heidelberg

Cover of the book Cell Biology of the Axon by Linda A. Lee, C.V. Dang
Cover of the book Biosphere-Atmosphere Exchange of Pollutants and Trace Substances by Linda A. Lee, C.V. Dang
Cover of the book Wie der Mensch seine Welt neu erschaffen hat by Linda A. Lee, C.V. Dang
Cover of the book Nuclear Physics with Polarized Particles by Linda A. Lee, C.V. Dang
Cover of the book Amination and Formation of sp2 C-N Bonds by Linda A. Lee, C.V. Dang
Cover of the book Experimentalphysik 2 by Linda A. Lee, C.V. Dang
Cover of the book Data Management and Query Processing in Semantic Web Databases by Linda A. Lee, C.V. Dang
Cover of the book Low Dielectric Constant Materials for IC Applications by Linda A. Lee, C.V. Dang
Cover of the book The Meniscus by Linda A. Lee, C.V. Dang
Cover of the book Digitale Produktion by Linda A. Lee, C.V. Dang
Cover of the book Krankheit und Recht by Linda A. Lee, C.V. Dang
Cover of the book The Industrial Organization of Banking by Linda A. Lee, C.V. Dang
Cover of the book A Primer on Scientific Programming with Python by Linda A. Lee, C.V. Dang
Cover of the book Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development by Linda A. Lee, C.V. Dang
Cover of the book Strategie und Management produzierender Unternehmen by Linda A. Lee, C.V. Dang
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy