Cancer Biomarkers in Body Fluids

Principles

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Specialties, Oncology
Cover of the book Cancer Biomarkers in Body Fluids by Gabriel D. Dakubo, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Gabriel D. Dakubo ISBN: 9783319015804
Publisher: Springer International Publishing Publication: September 1, 2016
Imprint: Springer Language: English
Author: Gabriel D. Dakubo
ISBN: 9783319015804
Publisher: Springer International Publishing
Publication: September 1, 2016
Imprint: Springer
Language: English

The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well.

This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.​​

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well.

This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.​​

More books from Springer International Publishing

Cover of the book The Interrelation of Phenomenology, Social Sciences and the Arts by Gabriel D. Dakubo
Cover of the book Energy Performance of Buildings by Gabriel D. Dakubo
Cover of the book Social Compliance Accounting by Gabriel D. Dakubo
Cover of the book Hydrothermal Processing in Biorefineries by Gabriel D. Dakubo
Cover of the book New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules by Gabriel D. Dakubo
Cover of the book The Roles of Remote Sensing in Nature Conservation by Gabriel D. Dakubo
Cover of the book Digital Science by Gabriel D. Dakubo
Cover of the book Superradiance by Gabriel D. Dakubo
Cover of the book Positional Plagiocephaly by Gabriel D. Dakubo
Cover of the book Stochastic Evolution Systems by Gabriel D. Dakubo
Cover of the book Reformation and Development in the Muslim World by Gabriel D. Dakubo
Cover of the book Rome and Irish Catholicism in the Atlantic World, 1622–1908 by Gabriel D. Dakubo
Cover of the book MultiMedia Modeling by Gabriel D. Dakubo
Cover of the book Sport Clubs in Europe by Gabriel D. Dakubo
Cover of the book Conceptual Shape Optimization of Entry Vehicles by Gabriel D. Dakubo
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy