Cancer Immunology and Immunotherapy

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Oncology
Cover of the book Cancer Immunology and Immunotherapy by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642141362
Publisher: Springer Berlin Heidelberg Publication: April 11, 2011
Imprint: Springer Language: English
Author:
ISBN: 9783642141362
Publisher: Springer Berlin Heidelberg
Publication: April 11, 2011
Imprint: Springer
Language: English

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

More books from Springer Berlin Heidelberg

Cover of the book Manual for the Planning and Implementation of Therapeutic Studies by
Cover of the book Voilà un homme - Über Goethe, die Menschen und das Leben by
Cover of the book Noninvasive Methods for the Quantification of Skin Functions by
Cover of the book Interactions Between Adjuvants, Agrochemicals and Target Organisms by
Cover of the book Sports Injuries by
Cover of the book Target Volume Definition in Radiation Oncology by
Cover of the book Functional Reconstruction of the Mandible by
Cover of the book Statistical Decision Theory by
Cover of the book Chlamydia pneumoniae and Chronic Diseases by
Cover of the book Towards a Model of Ocean Biogeochemical Processes by
Cover of the book Projektmanagement für die Praxis by
Cover of the book Materials with Complex Behaviour II by
Cover of the book A Study of the Stability of Contemporary Rural Chinese Society by
Cover of the book The Human Thymus by
Cover of the book Multicriteria Analysis by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy