Cardiac Arrhythmias: New Therapeutic Drugs and Devices

Proceedings of the Symposium on New Drugs and Devices, held at Philadelphia, PA October 4 and 5, 1984

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Internal Medicine, Cardiology
Cover of the book Cardiac Arrhythmias: New Therapeutic Drugs and Devices by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461325956
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461325956
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .

More books from Springer US

Cover of the book Controlled Hypotension in Neuroanaesthesia by
Cover of the book Knowledge Management for Development by
Cover of the book Aging, Reproduction, and the Climacteric by
Cover of the book The Practice of Coronary Artery Bypass Surgery by
Cover of the book Basic Functions of Language, Reading and Reading Disability by
Cover of the book Field-Programmable Analog Arrays by
Cover of the book Switched Time-Delay Systems by
Cover of the book Communications and Networking in Education by
Cover of the book The Reconstruction of Natural Zeolites by
Cover of the book Guanidino Compounds in Biology and Medicine by
Cover of the book Handbook of Diversity Issues in Health Psychology by
Cover of the book How to Invent by
Cover of the book Biennial Review of Infertility by
Cover of the book Hidden Markov Models in Finance by
Cover of the book Test Anxiety by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy