Cell Immortalization

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Cell Immortalization by , Springer Berlin Heidelberg
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Author: ISBN: 9783662062272
Publisher: Springer Berlin Heidelberg Publication: April 17, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783662062272
Publisher: Springer Berlin Heidelberg
Publication: April 17, 2013
Imprint: Springer
Language: English

The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera­ tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim­ ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris­ ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera­ tive phenotypes has to be seen using the perspective of comparative biology.

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The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera­ tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim­ ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris­ ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera­ tive phenotypes has to be seen using the perspective of comparative biology.

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