Clinically Relevant Resistance in Cancer Chemotherapy

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Clinically Relevant Resistance in Cancer Chemotherapy by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461511731
Publisher: Springer US Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461511731
Publisher: Springer US
Publication: December 6, 2012
Imprint: Springer
Language: English

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long­ term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.

More books from Springer US

Cover of the book Queuing Theory and Telecommunications by
Cover of the book Cancer Immunology: Innovative Approaches to Therapy by
Cover of the book Special Education Law by
Cover of the book Drug Evaluation in Angina Pectoris by
Cover of the book Household Composition in Latin America by
Cover of the book Geriatric Oncology by
Cover of the book Clinical Assessment of Child and Adolescent Personality and Behavior by
Cover of the book Functional and Morphological Imaging of the Endocrine System by
Cover of the book Acute Head Injury by
Cover of the book Data Access and Storage Management for Embedded Programmable Processors by
Cover of the book An Introduction to Trenchless Technology by
Cover of the book Legacy of Injustice by
Cover of the book Anaerobic Bacteria by
Cover of the book Voluntary Employee Withdrawal and Inattendance by
Cover of the book Open Networked "i-Learning" by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy