Coarse-Grained Modelling of DNA and DNA Self-Assembly
Nonfiction, Science & Nature, Technology, Nanotechnology, Science, Biological Sciences, Biophysics
| Author: | Thomas E. Ouldridge | ISBN: | 9783642305177 |
| Publisher: | Springer Berlin Heidelberg | Publication: | July 9, 2012 |
| Imprint: | Springer | Language: | English |
| Author: | Thomas E. Ouldridge |
| ISBN: | 9783642305177 |
| Publisher: | Springer Berlin Heidelberg |
| Publication: | July 9, 2012 |
| Imprint: | Springer |
| Language: | English |
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
