Combating Fungal Infections

Problems and Remedy

Nonfiction, Health & Well Being, Medical, Medical Science, Microbiology, Science & Nature, Science, Biological Sciences
Cover of the book Combating Fungal Infections by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642121739
Publisher: Springer Berlin Heidelberg Publication: August 3, 2010
Imprint: Springer Language: English
Author:
ISBN: 9783642121739
Publisher: Springer Berlin Heidelberg
Publication: August 3, 2010
Imprint: Springer
Language: English

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

More books from Springer Berlin Heidelberg

Cover of the book Recent Advances in the Processing of Wood-Plastic Composites by
Cover of the book Cortical Bone Healing after Internal Fixation and Infection by
Cover of the book Developing Grammars by
Cover of the book Small Organic Molecules on Surfaces by
Cover of the book Sports Injuries to the Shoulder and Elbow by
Cover of the book Stability and Synchronization Control of Stochastic Neural Networks by
Cover of the book Molecular and Cellular Enzymology by
Cover of the book Proceedings of the 2015 International Conference on Electrical and Information Technologies for Rail Transportation by
Cover of the book Evaluating Water Projects by
Cover of the book Intelligent Techniques in E-Commerce by
Cover of the book European Yearbook of International Economic Law 2011 by
Cover of the book Frontiers in Optical Methods by
Cover of the book Nano-Bio Probe Design and Its Application for Biochemical Analysis by
Cover of the book Clusters in Automotive and Information & Communication Technology by
Cover of the book Springer Handbook of Bio-/Neuro-Informatics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy