Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Organic
Cover of the book Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds by Stacey L. McDonald, Springer International Publishing
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Author: Stacey L. McDonald ISBN: 9783319388786
Publisher: Springer International Publishing Publication: August 18, 2016
Imprint: Springer Language: English
Author: Stacey L. McDonald
ISBN: 9783319388786
Publisher: Springer International Publishing
Publication: August 18, 2016
Imprint: Springer
Language: English

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

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