Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Organic
Cover of the book Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds by Stacey L. McDonald, Springer International Publishing
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Author: Stacey L. McDonald ISBN: 9783319388786
Publisher: Springer International Publishing Publication: August 18, 2016
Imprint: Springer Language: English
Author: Stacey L. McDonald
ISBN: 9783319388786
Publisher: Springer International Publishing
Publication: August 18, 2016
Imprint: Springer
Language: English

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

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This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

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