Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Oncology
Cover of the book Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy by , Springer International Publishing
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Author: ISBN: 9783319422237
Publisher: Springer International Publishing Publication: August 30, 2016
Imprint: Springer Language: English
Author:
ISBN: 9783319422237
Publisher: Springer International Publishing
Publication: August 30, 2016
Imprint: Springer
Language: English

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.

The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.

The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

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