Development of New Radical Cascades and Multi-Component Reactions

Application to the Synthesis of Nitrogen-Containing Heterocycles

Nonfiction, Science & Nature, Science, Chemistry, Technical & Industrial, Organic
Cover of the book Development of New Radical Cascades and Multi-Component Reactions by Marie-Helene Larraufie, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Marie-Helene Larraufie ISBN: 9783319013244
Publisher: Springer International Publishing Publication: December 16, 2013
Imprint: Springer Language: English
Author: Marie-Helene Larraufie
ISBN: 9783319013244
Publisher: Springer International Publishing
Publication: December 16, 2013
Imprint: Springer
Language: English

In this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals.The clarity and depth of the experimental section will be useful for students and researchers working in this field. 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals.The clarity and depth of the experimental section will be useful for students and researchers working in this field. 

More books from Springer International Publishing

Cover of the book Functional Analysis in Interdisciplinary Applications by Marie-Helene Larraufie
Cover of the book Implementing Campus Greening Initiatives by Marie-Helene Larraufie
Cover of the book Social-Emotional Prevention Programs for Preschool Children's Behavior Problems by Marie-Helene Larraufie
Cover of the book Orthodontic Management of the Developing Dentition by Marie-Helene Larraufie
Cover of the book Advanced Topics on Computer Vision, Control and Robotics in Mechatronics by Marie-Helene Larraufie
Cover of the book Sustainable Water Management in Urban Environments by Marie-Helene Larraufie
Cover of the book Fundamentals of Applied Multidimensional Scaling for Educational and Psychological Research by Marie-Helene Larraufie
Cover of the book Development Aid and Sustainable Economic Growth in Africa by Marie-Helene Larraufie
Cover of the book Scleroderma by Marie-Helene Larraufie
Cover of the book Research Challenges in Modeling and Simulation for Engineering Complex Systems by Marie-Helene Larraufie
Cover of the book Tensor Categories and Endomorphisms of von Neumann Algebras by Marie-Helene Larraufie
Cover of the book Feedback in Analog Circuits by Marie-Helene Larraufie
Cover of the book Enterprise Engineering by Marie-Helene Larraufie
Cover of the book Ecological and Evolutionary Modelling by Marie-Helene Larraufie
Cover of the book The UN System and Cities in Global Governance by Marie-Helene Larraufie
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy