DNA Replication Control in Microbial Cell Factories

Nonfiction, Science & Nature, Science, Biological Sciences, Microbiology, Biotechnology
Cover of the book DNA Replication Control in Microbial Cell Factories by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn ISBN: 9783319105338
Publisher: Springer International Publishing Publication: September 23, 2014
Imprint: Springer Language: English
Author: Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
ISBN: 9783319105338
Publisher: Springer International Publishing
Publication: September 23, 2014
Imprint: Springer
Language: English

This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of  activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested.

Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of  DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of  activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested.

Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of  DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.

More books from Springer International Publishing

Cover of the book Applied Nonautonomous and Random Dynamical Systems by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Risk Theory by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Exploring the Selfie by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Dynamics of Coupled Structures, Volume 4 by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Ontology Engineering by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Mathematical Modeling of Mitochondrial Swelling by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book The Philosophy of Science and Engineering Design by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Metabolism in Cancer by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Reading Fluency by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Trace-Based Post-Silicon Validation for VLSI Circuits by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Web Engineering by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Foreign Policy Analysis by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Crohn's Disease by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Mechanical Properties of Self-Compacting Concrete by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
Cover of the book Hybrid Practices in Moving Image Design by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy