Drug Resistance in Cancer Cells

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Medical Science, Pharmacology
Cover of the book Drug Resistance in Cancer Cells by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9780387894454
Publisher: Springer New York Publication: June 12, 2009
Imprint: Springer Language: English
Author:
ISBN: 9780387894454
Publisher: Springer New York
Publication: June 12, 2009
Imprint: Springer
Language: English

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.

More books from Springer New York

Cover of the book Reviews of Environmental Contamination and Toxicology Volume 212 by
Cover of the book International Handbook of Psychological Well-Being in Children and Adolescents by
Cover of the book Wireless Communication Electronics by
Cover of the book Psychiatric Neurotherapeutics by
Cover of the book Phonological Processes and Brain Mechanisms by
Cover of the book Understanding Crime Incidence Statistics by
Cover of the book Handbook of International Feminisms by
Cover of the book Family Firms in Transition by
Cover of the book On-chip High-Voltage Generator Design by
Cover of the book The Glaucoma Book by
Cover of the book Next Generation Sequencing and Sequence Assembly by
Cover of the book Google It by
Cover of the book Current Topics in Innate Immunity II by
Cover of the book Reviews of Environmental Contamination and Toxicology by
Cover of the book Elliptic Curves and Arithmetic Invariants by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy