EGFR Signaling Networks in Cancer Therapy

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book EGFR Signaling Networks in Cancer Therapy by , Humana Press
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781597453561
Publisher: Humana Press Publication: March 1, 2009
Imprint: Humana Press Language: English
Author:
ISBN: 9781597453561
Publisher: Humana Press
Publication: March 1, 2009
Imprint: Humana Press
Language: English

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

More books from Humana Press

Cover of the book Fluid and Electrolytes in Pediatrics by
Cover of the book Diseases of the Thyroid by
Cover of the book Alcohol Abuse Treatment by
Cover of the book Neuroinflammation by
Cover of the book Cardiac Drug Therapy by
Cover of the book Studies on Men's Health and Fertility by
Cover of the book Cardiac Tumor Pathology by
Cover of the book Pain in Children by
Cover of the book Office Urology by
Cover of the book Antimalarial Chemotherapy by
Cover of the book Multiple Visual Areas by
Cover of the book The Proteomics Protocols Handbook by
Cover of the book Diagnostic, Prognostic and Therapeutic Value of Gene Signatures by
Cover of the book Valvular Heart Disease by
Cover of the book Cytokine Knockouts by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy