Excitation-Contraction Coupling and Cardiac Contractile Force

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Cardiology
Cover of the book Excitation-Contraction Coupling and Cardiac Contractile Force by Donald Bers, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Donald Bers ISBN: 9789401006583
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author: Donald Bers
ISBN: 9789401006583
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction.
The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).
Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction.
The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).
Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

More books from Springer Netherlands

Cover of the book The Mucosal Immune System by Donald Bers
Cover of the book Physician-Assisted Suicide: What are the Issues? by Donald Bers
Cover of the book Bioethics Yearbook by Donald Bers
Cover of the book Thinking and Doing by Donald Bers
Cover of the book High Pressure Bioscience by Donald Bers
Cover of the book The Business of Shipping by Donald Bers
Cover of the book South American and Antarctic Continental Cenozoic Birds by Donald Bers
Cover of the book Evolution of Laurussia by Donald Bers
Cover of the book Environmental and Technology Policy in Europe by Donald Bers
Cover of the book Imaging Radar for Resources Surveys by Donald Bers
Cover of the book Functional Genomics and Evolution of Photosynthetic Systems by Donald Bers
Cover of the book Collected Papers II by Donald Bers
Cover of the book Under the Counter and Over the Border by Donald Bers
Cover of the book Law and Politics of the Danube by Donald Bers
Cover of the book Studies in Philosophical Psychology by Donald Bers
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy