Fetal Islet Transplantation

Implications for Diabetes

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Internal Medicine, Endocrinology & Metabolism
Cover of the book Fetal Islet Transplantation by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461237662
Publisher: Springer New York Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461237662
Publisher: Springer New York
Publication: December 6, 2012
Imprint: Springer
Language: English

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man­ Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man­ Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

More books from Springer New York

Cover of the book Clinician's Guide to Diagnostic Imaging by
Cover of the book Calculus Without Derivatives by
Cover of the book Residue Reviews by
Cover of the book From Neurology to Methodology and Back by
Cover of the book Working Knowledge by
Cover of the book Multidimensional Poverty Measurement by
Cover of the book MRI Physics for Physicians by
Cover of the book Breast Surgical Techniques and Interdisciplinary Management by
Cover of the book Forensic Epidemiology in the Global Context by
Cover of the book Parent-Teen Communication by
Cover of the book Advanced Materials for Thermal Management of Electronic Packaging by
Cover of the book The Primary Auditory Neurons of the Mammalian Cochlea by
Cover of the book An Introduction to Hopf Algebras by
Cover of the book Flow Boiling in Microgap Channels by
Cover of the book Computational Strategies Towards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy