Fetal Islet Transplantation

Implications for Diabetes

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Internal Medicine, Endocrinology & Metabolism
Cover of the book Fetal Islet Transplantation by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461237662
Publisher: Springer New York Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461237662
Publisher: Springer New York
Publication: December 6, 2012
Imprint: Springer
Language: English

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man­ Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man­ Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

More books from Springer New York

Cover of the book After Ethics by
Cover of the book Relativistic Many-Body Theory by
Cover of the book Computational and Analytical Mathematics by
Cover of the book Clinical PET-CT in Radiology by
Cover of the book Rheology of Complex Fluids by
Cover of the book Integrative Weight Management by
Cover of the book Factors Affecting the Removal of Ammonia from Air on Carbonaceous Materials by
Cover of the book Developing and Maintaining Police-Researcher Partnerships to Facilitate Research Use by
Cover of the book Wave Propagation in Solid and Porous Half-Space Media by
Cover of the book Anesthetic and Obstetric Management of High-Risk Pregnancy by
Cover of the book Comparative Archaeologies by
Cover of the book Teleneurology in Practice by
Cover of the book Bioinformatics by
Cover of the book Imaging the Southern Sky by
Cover of the book Franchisees as Consumers by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy