Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Specialties, Internal Medicine, Neuroscience, Science & Nature, Science
Cover of the book Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors by , Springer Vienna
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783709192061
Publisher: Springer Vienna Publication: March 8, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783709192061
Publisher: Springer Vienna
Publication: March 8, 2013
Imprint: Springer
Language: English

Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.

More books from Springer Vienna

Cover of the book Novel Technologies for Vaccine Development by
Cover of the book New Aspects on Tethyan Cretaceous Fossil Assemblages by
Cover of the book Drug Therapy for the Elderly by
Cover of the book Dynamics of the Singing Voice by
Cover of the book Field-Flow Fractionation in Biopolymer Analysis by
Cover of the book Geriatrische Notfallversorgung by
Cover of the book Iron in Central Nervous System Disorders by
Cover of the book Transesophageal Echocardiography by
Cover of the book A Short Practice of Spinal Surgery by
Cover of the book Autoimmune Diseases of the Skin by
Cover of the book Obstetric Fistula by
Cover of the book The Microtubule Cytoskeleton by
Cover of the book Store-operated Ca2+ entry (SOCE) pathways by
Cover of the book Quantitative EPR by
Cover of the book Burn Care and Treatment by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy