Genetic Models of Immune and Inflammatory Diseases

Nonfiction, Health & Well Being, Medical, Specialties, Gynecology & Obstetrics, Oncology
Cover of the book Genetic Models of Immune and Inflammatory Diseases by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461223764
Publisher: Springer New York Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461223764
Publisher: Springer New York
Publication: December 6, 2012
Imprint: Springer
Language: English

This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.

More books from Springer New York

Cover of the book Data Acquisition Systems by
Cover of the book Exceptional Children by
Cover of the book Improving Aid Effectiveness in Global Health by
Cover of the book How Einstein Created Relativity out of Physics and Astronomy by
Cover of the book Building a Roll-Off Roof or Dome Observatory by
Cover of the book Systems Biology of Apoptosis by
Cover of the book Encephalitis Lethargica by
Cover of the book The Organization of Critical Care by
Cover of the book Ageing in Australia by
Cover of the book Chemical Signals in Vertebrates 12 by
Cover of the book Pathobiology of Cancer Regimen-Related Toxicities by
Cover of the book Introduction to Mixed-Signal, Embedded Design by
Cover of the book The Internet for Nurses and Allied Health Professionals by
Cover of the book Logic Synthesis for Genetic Diseases by
Cover of the book Atlas of Esophagus and Stomach Pathology by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy