Genetic Variants in Alzheimer's Disease

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Specialties, Internal Medicine, Neuroscience
Cover of the book Genetic Variants in Alzheimer's Disease by , Springer New York
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Author: ISBN: 9781461473091
Publisher: Springer New York Publication: June 22, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781461473091
Publisher: Springer New York
Publication: June 22, 2013
Imprint: Springer
Language: English

Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades.  This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s.  These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.  The aim of this book is to put all of the recent genetic data on these new genes into context.  Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

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Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades.  This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s.  These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.  The aim of this book is to put all of the recent genetic data on these new genes into context.  Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

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