Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Nonfiction, Science & Nature, Science, Chemistry, Organic, Biological Sciences, Biochemistry
Cover of the book Heteroaromatic Lipoxin A4 Analogues by Colm Duffy, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Colm Duffy ISBN: 9783642246326
Publisher: Springer Berlin Heidelberg Publication: January 10, 2012
Imprint: Springer Language: English
Author: Colm Duffy
ISBN: 9783642246326
Publisher: Springer Berlin Heidelberg
Publication: January 10, 2012
Imprint: Springer
Language: English

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

More books from Springer Berlin Heidelberg

Cover of the book Digital Photogrammetry by Colm Duffy
Cover of the book Current Research in Ophthalmic Electron Microscopy by Colm Duffy
Cover of the book Advances in Wireless Sensor Networks by Colm Duffy
Cover of the book Percutaneous Vascular Recanalization by Colm Duffy
Cover of the book Scientific Computing and Cultural Heritage by Colm Duffy
Cover of the book Early Development of the Adrenal Glands in the Grass Snake Natrix natrix L. (Lepidosauria, Serpentes) by Colm Duffy
Cover of the book Proceedings of the FISITA 2012 World Automotive Congress by Colm Duffy
Cover of the book New Discoveries on the β-Hydride Elimination by Colm Duffy
Cover of the book Ecology and Evolution of the Freshwater Mussels Unionoida by Colm Duffy
Cover of the book Endocrine Treatment of Breast Cancer by Colm Duffy
Cover of the book Transcultural Turbulences by Colm Duffy
Cover of the book Progress in Botany 72 by Colm Duffy
Cover of the book Adjuvant Chemotherapy of Breast Cancer by Colm Duffy
Cover of the book Electric Energy Storage Systems by Colm Duffy
Cover of the book Radiology of AIDS by Colm Duffy
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy