Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation

Nonfiction, Science & Nature, Science, Chemistry, Organic, Biological Sciences, Biochemistry
Cover of the book Heteroaromatic Lipoxin A4 Analogues by Colm Duffy, Springer Berlin Heidelberg
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Author: Colm Duffy ISBN: 9783642246326
Publisher: Springer Berlin Heidelberg Publication: January 10, 2012
Imprint: Springer Language: English
Author: Colm Duffy
ISBN: 9783642246326
Publisher: Springer Berlin Heidelberg
Publication: January 10, 2012
Imprint: Springer
Language: English

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

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In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

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