Hormonal Carcinogenesis III

Proceedings of the Third International Symposium

Nonfiction, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Hormonal Carcinogenesis III by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461220923
Publisher: Springer New York Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9781461220923
Publisher: Springer New York
Publication: December 6, 2012
Imprint: Springer
Language: English

Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

More books from Springer New York

Cover of the book Essentials of Clinical Mycology by
Cover of the book Minimally Invasive Approaches to Colon and Rectal Disease by
Cover of the book Demand Flexibility in Supply Chain Planning by
Cover of the book African Americans and HIV/AIDS by
Cover of the book Solar Power Satellites by
Cover of the book Introduction to Cardiopulmonary Exercise Testing by
Cover of the book Symplasmic Transport in Vascular Plants by
Cover of the book Probability-1 by
Cover of the book The Ideal Result by
Cover of the book Bayesian Networks and Influence Diagrams: A Guide to Construction and Analysis by
Cover of the book Youth Criminal Justice Policy in Canada by
Cover of the book The H-Function by
Cover of the book Characterization of Terahertz Emission from High Resistivity Fe-doped Bulk Ga0.69In0.31As Based Photoconducting Antennas by
Cover of the book Reviews of Environmental Contamination and Toxicology 198 by
Cover of the book Environmental Adaptations and Stress Tolerance of Plants in the Era of Climate Change by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy