Human Chromosome Atlas

Introduction to diagnostics of structural aberrations

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Medical Science, Genetics
Cover of the book Human Chromosome Atlas by Claudia Behrend, Javad Karimzad Hagh, Parvin Mehdipour, Gesa Schwanitz, Springer International Publishing
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Author: Claudia Behrend, Javad Karimzad Hagh, Parvin Mehdipour, Gesa Schwanitz ISBN: 9783319540993
Publisher: Springer International Publishing Publication: July 6, 2017
Imprint: Springer Language: English
Author: Claudia Behrend, Javad Karimzad Hagh, Parvin Mehdipour, Gesa Schwanitz
ISBN: 9783319540993
Publisher: Springer International Publishing
Publication: July 6, 2017
Imprint: Springer
Language: English

This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.

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This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.

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