Immune Infertility

The Impact of Immune Reactions on Human Infertility

Nonfiction, Health & Well Being, Health, Ailments & Diseases, Genetic, Medical, Specialties, Gynecology & Obstetrics
Cover of the book Immune Infertility by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642013799
Publisher: Springer Berlin Heidelberg Publication: August 17, 2009
Imprint: Springer Language: English
Author:
ISBN: 9783642013799
Publisher: Springer Berlin Heidelberg
Publication: August 17, 2009
Imprint: Springer
Language: English

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2–30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2–30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

More books from Springer Berlin Heidelberg

Cover of the book Cloud-Service-Zertifizierung by
Cover of the book Atlas of Brain Mapping by
Cover of the book Satellites and Defective Viral RNAs by
Cover of the book A Measure Theoretical Approach to Quantum Stochastic Processes by
Cover of the book Deutschlands Norden by
Cover of the book Der verborgene Hunger by
Cover of the book Die Vierte Dimension der Schöpfung by
Cover of the book Study on Climate Change in Southwestern China by
Cover of the book Nursing Informatics ’91 by
Cover of the book Life Sciences and Radiation by
Cover of the book International Finance and Open-Economy Macroeconomics by
Cover of the book Das optimistische Gehirn by
Cover of the book The Efferent System of Cranial Nerve Nuclei: A Comparative Neuromorphological Study by
Cover of the book Intelligent Information and Database Systems by
Cover of the book Glaucoma Update VI by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy