Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Oncology
Cover of the book Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology by Witold Lasek, Radoslaw Zagozdzon, Marek Jakóbisiak, Springer International Publishing
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Author: Witold Lasek, Radoslaw Zagozdzon, Marek Jakóbisiak ISBN: 9783319469065
Publisher: Springer International Publishing Publication: September 23, 2016
Imprint: Springer Language: English
Author: Witold Lasek, Radoslaw Zagozdzon, Marek Jakóbisiak
ISBN: 9783319469065
Publisher: Springer International Publishing
Publication: September 23, 2016
Imprint: Springer
Language: English

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

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This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

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