Ion Channel Regulation

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Biochemistry
Cover of the book Ion Channel Regulation by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie ISBN: 9780080526454
Publisher: Elsevier Science Publication: April 13, 1999
Imprint: Academic Press Language: English
Author: Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
ISBN: 9780080526454
Publisher: Elsevier Science
Publication: April 13, 1999
Imprint: Academic Press
Language: English

Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.

  • Reviews brain functioning at the fundamental, molecular level
  • Describes key systems that control signaling between and within cells
  • Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.

More books from Elsevier Science

Cover of the book Computational Methods in Reactor Shielding by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Secrets Stolen, Fortunes Lost by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Biodegradable and Sustainable Fibres by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Zeolites and Ordered Mesoporous Materials: Progress and Prospects by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Introduction to Electrophysiological Methods and Instrumentation by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Managing Academic Libraries by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book The Handbook for School Safety and Security by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Entropy Principle for the Development of Complex Biotic Systems by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Advances in Ceramic Matrix Composites by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Developments in Surface Contamination and Cleaning, Volume 7 by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Future Energy by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Ni-free Ti-based Shape Memory Alloys by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Advances in Atomic, Molecular, and Optical Physics by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Fossil Parasites by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
Cover of the book Fluid Power Dynamics by Paul Greengard, Angus C. Nairn, Shirish Shenolikar, David L. Armstrong, Sandra Rossie
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy