Mathematical Modelling of Chromosome Replication and Replicative Stress

Nonfiction, Science & Nature, Science, Biological Sciences, Biophysics, Physics, General Physics
Cover of the book Mathematical Modelling of Chromosome Replication and Replicative Stress by Jens Karschau, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Jens Karschau ISBN: 9783319088617
Publisher: Springer International Publishing Publication: July 11, 2014
Imprint: Springer Language: English
Author: Jens Karschau
ISBN: 9783319088617
Publisher: Springer International Publishing
Publication: July 11, 2014
Imprint: Springer
Language: English

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.

This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?.

A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

More books from Springer International Publishing

Cover of the book More Harm than Good? by Jens Karschau
Cover of the book Access to Bank Credit and SME Financing by Jens Karschau
Cover of the book Financial Dimensions of Marketing Decisions by Jens Karschau
Cover of the book Sustainable Development Goals and Sustainable Supply Chains in the Post-global Economy by Jens Karschau
Cover of the book Passive and Active Measurement by Jens Karschau
Cover of the book Smart Energy Research. At the Crossroads of Engineering, Economics, and Computer Science by Jens Karschau
Cover of the book Engineering Dynamics by Jens Karschau
Cover of the book Computational Diffusion MRI by Jens Karschau
Cover of the book The Art and Science of Rotating Field Machines Design: A Practical Approach by Jens Karschau
Cover of the book Parameterized and Exact Computation by Jens Karschau
Cover of the book Combining Interval, Probabilistic, and Other Types of Uncertainty in Engineering Applications by Jens Karschau
Cover of the book Geoinformation for Informed Decisions by Jens Karschau
Cover of the book Technology Run Amok by Jens Karschau
Cover of the book Handbook of Lifelong Learning for Sustainable Development by Jens Karschau
Cover of the book The Romance of Science: Essays in Honour of Trevor H. Levere by Jens Karschau
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy