Membrane Transport Mechanism

3D Structure and Beyond

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Biochemistry
Cover of the book Membrane Transport Mechanism by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642538391
Publisher: Springer Berlin Heidelberg Publication: March 13, 2014
Imprint: Springer Language: English
Author:
ISBN: 9783642538391
Publisher: Springer Berlin Heidelberg
Publication: March 13, 2014
Imprint: Springer
Language: English

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.

More books from Springer Berlin Heidelberg

Cover of the book Culture and Neural Frames of Cognition and Communication by
Cover of the book Pathology of the Gastro-Intestinal Tract by
Cover of the book Potassium Argon Dating by
Cover of the book Polyhydroxyalkanoates from Palm Oil: Biodegradable Plastics by
Cover of the book Stochastik in den Ingenieurwissenschaften by
Cover of the book Lead-Seeking Approaches by
Cover of the book Asymptotic Theory of Weakly Dependent Random Processes by
Cover of the book Mycorrhizas - Functional Processes and Ecological Impact by
Cover of the book Modification of Radiation Response by
Cover of the book Silicone Oil in the Treatment of Complicated Retinal Detachments by
Cover of the book Breath Odors by
Cover of the book Drip Irrigation by
Cover of the book Antifungal Metabolites from Plants by
Cover of the book Chest Trauma by
Cover of the book Advanced Field-Solver Techniques for RC Extraction of Integrated Circuits by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy