Microcalorimetry of Macromolecules

The Physical Basis of Biological Structures

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Microcalorimetry of Macromolecules by Peter L. Privalov, Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Peter L. Privalov ISBN: 9781118337493
Publisher: Wiley Publication: May 29, 2012
Imprint: Wiley Language: English
Author: Peter L. Privalov
ISBN: 9781118337493
Publisher: Wiley
Publication: May 29, 2012
Imprint: Wiley
Language: English

Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques

Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information.

Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers:

  • The use of supersensitive calorimetric instruments, including micro and nano-calorimeters for measuring the heat of isothermal reactions (Isothermal Titration Nano-Calorimeter), the heat capacities over a broad temperature range (Scanning Nano-Calorimeter), and pressure effects (Pressure Perturbation Nano-Calorimeter)
  • Two of the simplest but key structural elements: the α and polyproline helices and their complexes, the α-helical coiled-coil, and the pyroline coiled-coils
  • Complicated macromolecular formations, including small globular proteins, multidomain proteins and their complexes, and nucleic acids
  • Numerous examples of measuring the ground state of protein energetics, as well as changes seen when proteins interact

The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques

Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information.

Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers:

The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.

More books from Wiley

Cover of the book Handbook of Metathesis, Volume 2 by Peter L. Privalov
Cover of the book Starting an Online Business All-in-One For Dummies by Peter L. Privalov
Cover of the book Ultra Low Power Electronics and Adiabatic Solutions by Peter L. Privalov
Cover of the book Magnetohydrodynamic Stability of Tokamaks by Peter L. Privalov
Cover of the book Solid State Characterization of Pharmaceuticals by Peter L. Privalov
Cover of the book What is a Social Movement? by Peter L. Privalov
Cover of the book Electromagnetic Well Logging by Peter L. Privalov
Cover of the book Veterinary Neuropathology by Peter L. Privalov
Cover of the book Strategic Decisions and Weak Signals by Peter L. Privalov
Cover of the book Transdisciplinary Public Health by Peter L. Privalov
Cover of the book Global Repo Markets by Peter L. Privalov
Cover of the book The Skilled Facilitator by Peter L. Privalov
Cover of the book Intelligent M&A by Peter L. Privalov
Cover of the book Organic Gardening For Dummies by Peter L. Privalov
Cover of the book Mobile Agents in Networking and Distributed Computing by Peter L. Privalov
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy