Modified Nucleic Acids in Biology and Medicine

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Modified Nucleic Acids in Biology and Medicine by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319341750
Publisher: Springer International Publishing Publication: July 29, 2016
Imprint: Springer Language: English
Author:
ISBN: 9783319341750
Publisher: Springer International Publishing
Publication: July 29, 2016
Imprint: Springer
Language: English

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.

The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.

Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.

This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.

The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.

Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.

This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

 

More books from Springer International Publishing

Cover of the book Energy Transition by
Cover of the book The Nature of School Leadership by
Cover of the book Combinatorics on Words by
Cover of the book Growth Curve Models and Applications by
Cover of the book Biomimetic and Biohybrid Systems by
Cover of the book Multidisciplinary Care of the Head and Neck Cancer Patient by
Cover of the book Eco-Innovation and the Development of Business Models by
Cover of the book Advances in Computer Games by
Cover of the book Dialysis Access Cases by
Cover of the book Optical Communications by
Cover of the book Numerical Methods and Applications by
Cover of the book Advances in Multimedia Information Processing – PCM 2018 by
Cover of the book Quantum Mechanics for Pedestrians 2: Applications and Extensions by
Cover of the book Religious Complexity in the Public Sphere by
Cover of the book Kinetic Theory of Nonequilibrium Ensembles, Irreversible Thermodynamics, and Generalized Hydrodynamics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy