Multifunctional Gold Nanostars for Cancer Theranostics

Nonfiction, Science & Nature, Science, Other Sciences, Nanostructures, Health & Well Being, Medical, Specialties, Oncology, Technology
Cover of the book Multifunctional Gold Nanostars for Cancer Theranostics by Yang Liu, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Yang Liu ISBN: 9783319749204
Publisher: Springer International Publishing Publication: March 15, 2018
Imprint: Springer Language: English
Author: Yang Liu
ISBN: 9783319749204
Publisher: Springer International Publishing
Publication: March 15, 2018
Imprint: Springer
Language: English

This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.

Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.

The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.

Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.

The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

More books from Springer International Publishing

Cover of the book First-Trimester Ultrasound by Yang Liu
Cover of the book Knowledge Management by Yang Liu
Cover of the book Urban Mobility in Modern China by Yang Liu
Cover of the book Data Privacy Management and Security Assurance by Yang Liu
Cover of the book Mastering Scale and Complexity in Software Reuse by Yang Liu
Cover of the book Nineteenth-Century Individualism and the Market Economy by Yang Liu
Cover of the book Nanomaterials in Extreme Environments by Yang Liu
Cover of the book PET/CT in Cancer of Unknown Primary by Yang Liu
Cover of the book Utility Communication Networks and Services by Yang Liu
Cover of the book Coastal Ocean Observing by Yang Liu
Cover of the book Financial Modelling with Forward-looking Information by Yang Liu
Cover of the book Mathematical Practitioners and the Transformation of Natural Knowledge in Early Modern Europe by Yang Liu
Cover of the book Excitation Energies and Properties of Open-Shell Singlet Molecules by Yang Liu
Cover of the book New Business and Regulatory Strategies in the Postal Sector by Yang Liu
Cover of the book Spectrum Sharing for Wireless Communications by Yang Liu
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy