Myeloid-Derived Suppressor Cells and Cancer

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Specialties, Oncology
Cover of the book Myeloid-Derived Suppressor Cells and Cancer by David Escors, Grazyna Kochan, James E. Talmadge, Jo A. Van Ginderachter, Karine Breckpot, Springer International Publishing
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Author: David Escors, Grazyna Kochan, James E. Talmadge, Jo A. Van Ginderachter, Karine Breckpot ISBN: 9783319268217
Publisher: Springer International Publishing Publication: March 15, 2016
Imprint: Springer Language: English
Author: David Escors, Grazyna Kochan, James E. Talmadge, Jo A. Van Ginderachter, Karine Breckpot
ISBN: 9783319268217
Publisher: Springer International Publishing
Publication: March 15, 2016
Imprint: Springer
Language: English

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

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The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

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