Nephrotoxicity

In Vitro to In Vivo Animals to Man

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Nephrology
Cover of the book Nephrotoxicity by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781475720402
Publisher: Springer US Publication: June 29, 2013
Imprint: Springer Language: English
Author:
ISBN: 9781475720402
Publisher: Springer US
Publication: June 29, 2013
Imprint: Springer
Language: English

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.

More books from Springer US

Cover of the book Teaching Students in Clinical Settings by
Cover of the book Writing for Health Professionals by
Cover of the book Atherosclerosis, Hypertension and Diabetes by
Cover of the book Farewell Fossil Fuels by
Cover of the book Advances in Biofuels by
Cover of the book Direct Myocardial Revascularization: History, Methodology, Technology by
Cover of the book Executive Compensation and Shareholder Value by
Cover of the book Depression by
Cover of the book Contemporary Nephrology by
Cover of the book The Partnership Model in Human Services by
Cover of the book Encyclopedia of Prehistory by
Cover of the book Intelligent Networks and Intelligence in Networks by
Cover of the book WIG Craft and Ekranoplan by
Cover of the book Flavonoids in Cell Function by
Cover of the book Captopril and Hypertension by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy