Neuropilin

From Nervous System to Vascular and Tumor Biology

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Cardiology, Neuroscience, Science & Nature, Science
Cover of the book Neuropilin by , Springer US
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461501190
Publisher: Springer US Publication: April 27, 2011
Imprint: Springer Language: English
Author:
ISBN: 9781461501190
Publisher: Springer US
Publication: April 27, 2011
Imprint: Springer
Language: English

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica­ tion of several families of adhesion molecules, well conserved throughout evolu­ tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi­ gration, or differentiation depends on both cell surface adhesion properties and acti­ vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen­ esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro­ pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica­ tion of several families of adhesion molecules, well conserved throughout evolu­ tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi­ gration, or differentiation depends on both cell surface adhesion properties and acti­ vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen­ esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro­ pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.

More books from Springer US

Cover of the book Wavelets by
Cover of the book Geology and Society by
Cover of the book Biopsychosocial Approaches in Primary Care by
Cover of the book Fundamentals of Cybernetics by
Cover of the book Practitioner's Guide to Empirically-Based Measures of Depression by
Cover of the book Dictionary of Food and Ingredients by
Cover of the book Central Auditory Processing and Neural Modeling by
Cover of the book Delay Fault Testing for VLSI Circuits by
Cover of the book Chlamydia by
Cover of the book Toward Consilience by
Cover of the book Analysis and Damping Control of Power System Low-frequency Oscillations by
Cover of the book Clinical Management of Memory Problems by
Cover of the book Computational Techniques for the Summation of Series by
Cover of the book International Regulation of Underwater Sound by
Cover of the book Peak Flow Measurement by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy