New Aspects in Hypertension Adrenoceptors

Symposium, November 1985, Munich

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Specialties, Internal Medicine, Cardiology
Cover of the book New Aspects in Hypertension Adrenoceptors by B. Riepl, Springer Berlin Heidelberg
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Author: B. Riepl ISBN: 9783642714184
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author: B. Riepl
ISBN: 9783642714184
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

This book reports on the current state of knowledge about adreno­ ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit­ ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under­ standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica­ tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ­ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be­ coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel­ opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph­ eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions.

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This book reports on the current state of knowledge about adreno­ ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit­ ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under­ standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica­ tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ­ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be­ coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel­ opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph­ eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions.

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