New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

Nonfiction, Science & Nature, Science, Chemistry, Organic, Technical & Industrial
Cover of the book New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations by Xiangyu Chen, Springer Singapore
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Xiangyu Chen ISBN: 9789811028991
Publisher: Springer Singapore Publication: December 20, 2016
Imprint: Springer Language: English
Author: Xiangyu Chen
ISBN: 9789811028991
Publisher: Springer Singapore
Publication: December 20, 2016
Imprint: Springer
Language: English

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α,β-unsaturated carboxylic acids were first successfully employed to generate the α,β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and α,β-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of β-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging β-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via γ-addition. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available α,β-unsaturated carboxylic acids were first successfully employed to generate the α,β-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

More books from Springer Singapore

Cover of the book The Chinese Philosophy of Fate by Xiangyu Chen
Cover of the book Investigations in Computational Sarcasm by Xiangyu Chen
Cover of the book Intelligent Systems, Technologies and Applications by Xiangyu Chen
Cover of the book Catheter Ablation by Xiangyu Chen
Cover of the book Design and Control of Highly Conductive Single-Molecule Junctions by Xiangyu Chen
Cover of the book Evolutionary Approach to Machine Learning and Deep Neural Networks by Xiangyu Chen
Cover of the book Real-Time Coaching and Pre-Service Teacher Education by Xiangyu Chen
Cover of the book Proceedings of the Second International Conference on Intelligent Transportation by Xiangyu Chen
Cover of the book Methodology of Judicial Proof and Presumption by Xiangyu Chen
Cover of the book Sustainability Issues in Civil Engineering by Xiangyu Chen
Cover of the book Impact of Climate Change on Water Resources by Xiangyu Chen
Cover of the book The 2016 Mw 7.1 Kumamoto Earthquake by Xiangyu Chen
Cover of the book Spatial Polarization Characteristics of Radar Antenna by Xiangyu Chen
Cover of the book Cancer and Chemoprevention: An Overview by Xiangyu Chen
Cover of the book Phase II Clinical Development of New Drugs by Xiangyu Chen
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy