Pharmacokinetics in Drug Development

Problems and Challenges in Oncology, Volume 4

Nonfiction, Health & Well Being, Medical, Specialties, Pharmacy, Oncology, Science & Nature, Technology
Cover of the book Pharmacokinetics in Drug Development by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319390536
Publisher: Springer International Publishing Publication: October 6, 2016
Imprint: Springer Language: English
Author:
ISBN: 9783319390536
Publisher: Springer International Publishing
Publication: October 6, 2016
Imprint: Springer
Language: English

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies.  This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals,  clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.        

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies.  This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals,  clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.        

More books from Springer International Publishing

Cover of the book The End of the Democratic State by
Cover of the book Urban Air Pollution Monitoring by Ground-Based Stations and Satellite Data by
Cover of the book Culture, Organizations, and Work by
Cover of the book The Identification, Assessment, and Treatment of Adults Who Abuse Animals by
Cover of the book Competence Based Education and Training (CBET) and the End of Human Learning by
Cover of the book Interdisciplinary Topics in Applied Mathematics, Modeling and Computational Science by
Cover of the book Games and Learning Alliance by
Cover of the book Adaptive Semantics Visualization by
Cover of the book The Consequences of the Crisis on European Integration and on the Member States by
Cover of the book Endoscopic Surgery of the Lacrimal Drainage System by
Cover of the book Protecting Children Against Bullying and Its Consequences by
Cover of the book The Aristotelian Mechanics by
Cover of the book Correlated Random Systems: Five Different Methods by
Cover of the book Irrepressible Truth by
Cover of the book Application of Microalgae in Wastewater Treatment by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy