Phosphodiesterases as Drug Targets

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Phosphodiesterases as Drug Targets by , Springer Berlin Heidelberg
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Author: ISBN: 9783642179693
Publisher: Springer Berlin Heidelberg Publication: June 21, 2011
Imprint: Springer Language: English
Author:
ISBN: 9783642179693
Publisher: Springer Berlin Heidelberg
Publication: June 21, 2011
Imprint: Springer
Language: English

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

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Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

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