Primary Biliary Cirrhosis

From Pathogenesis to Clinical Treatment

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Gastroenterology
Cover of the book Primary Biliary Cirrhosis by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789401148849
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9789401148849
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

The condition of prolonged obstructive jaundice with patent bile ducts was first described in 1851 by Addison and Gull of Guy's Hospital, London. The term primary biliary cirrhosis (PBC) was defined in 1950 by Ahrens and colleagues of the Rockefeller Institute, New York. The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer. If the diagnosis is made earlier, the end stages are rarely reached as death is replaced by liver transplantation. On November 6th 1997, in Chicago, an International Faculty discussed in depth the clinical features, pathogenesis and treatment of PBC, no longer considered a rare disease. The course of PBC is long, but some 18 years after the discovery of a positive mitochondrial antibody test in a symptom­ free patient with normal serum biochemistry, 83% will have developed abnormal tests and 76% will be symptomatic. Identification of those who will progress rapidly is difficult. The serum antimitochondrial profile may be useful but this is a very specialist technique. Mathematical prognostic models are useful in therapeutic trials and in the selection and timing of patients for liver transplantation but have limited value in individual patients. An increasing serum bilirubin level remains the most important indicator of rapid progression. Its value however can be negated by the use of ursodeoxycholic acid which has a bilirubin-lowering effect.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The condition of prolonged obstructive jaundice with patent bile ducts was first described in 1851 by Addison and Gull of Guy's Hospital, London. The term primary biliary cirrhosis (PBC) was defined in 1950 by Ahrens and colleagues of the Rockefeller Institute, New York. The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer. If the diagnosis is made earlier, the end stages are rarely reached as death is replaced by liver transplantation. On November 6th 1997, in Chicago, an International Faculty discussed in depth the clinical features, pathogenesis and treatment of PBC, no longer considered a rare disease. The course of PBC is long, but some 18 years after the discovery of a positive mitochondrial antibody test in a symptom­ free patient with normal serum biochemistry, 83% will have developed abnormal tests and 76% will be symptomatic. Identification of those who will progress rapidly is difficult. The serum antimitochondrial profile may be useful but this is a very specialist technique. Mathematical prognostic models are useful in therapeutic trials and in the selection and timing of patients for liver transplantation but have limited value in individual patients. An increasing serum bilirubin level remains the most important indicator of rapid progression. Its value however can be negated by the use of ursodeoxycholic acid which has a bilirubin-lowering effect.

More books from Springer Netherlands

Cover of the book The Social Process of Scientific Investigation by
Cover of the book Believing and Accepting by
Cover of the book International Research Handbook on Values Education and Student Wellbeing by
Cover of the book Teaching for Effective Learning in Higher Education by
Cover of the book Scientific Uncertainty and Its Influence on the Public Communication Process by
Cover of the book Test Procedures for the Blood Compatibility of Biomaterials by
Cover of the book Digital Telephony and Network Integration by
Cover of the book Globalization and Human Rights by
Cover of the book Cell Death in Mammalian Ovary by
Cover of the book Motion and Knowledge in the Changing Early Modern World by
Cover of the book Process Theories by
Cover of the book Features, Categories and the Syntax of A-Positions by
Cover of the book Neanderthal Lifeways, Subsistence and Technology by
Cover of the book The Creative Matrix of the Origins by
Cover of the book Handbook of Printed Circuit Manufacturing by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy