Primary Progressive Multiple Sclerosis

Nonfiction, Health & Well Being, Medical, Allied Health Services, Radiological & Ultrasound, Specialties, Internal Medicine, Neurology
Cover of the book Primary Progressive Multiple Sclerosis by , Springer Milan
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9788847022348
Publisher: Springer Milan Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9788847022348
Publisher: Springer Milan
Publication: December 6, 2012
Imprint: Springer
Language: English

"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin­ ical trials have excluded PPMS patients on two counts. Clinical worsening devel­ ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi­ ence suggests that the results may not be dramatic.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin­ ical trials have excluded PPMS patients on two counts. Clinical worsening devel­ ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi­ ence suggests that the results may not be dramatic.

More books from Springer Milan

Cover of the book Chest, Musculoskeleton, G.I. and Abdomen, Urinary Tract by
Cover of the book Lungscapes by
Cover of the book Injections in Aesthetic Medicine by
Cover of the book Neurosonological Evaluation of Cerebral Venous Outflow by
Cover of the book Innovation in Esophageal Surgery by
Cover of the book Mechanics of Breathing by
Cover of the book Computing Qualitatively Correct Approximations of Balance Laws by
Cover of the book Regional Anaesthesia Analgesia and Pain Management by
Cover of the book Imaging Coronary Arteries by
Cover of the book Sepsis and Organ Dysfunction by
Cover of the book History of Virtual Work Laws by
Cover of the book Atlas of Male Genital Disorders by
Cover of the book Metabolism and Artificial Nutrition in the Critically Ill by
Cover of the book Wearing Embodied Emotions by
Cover of the book MDCT and MRI in Genitourinary Imaging by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy