Programmed Cells from Basic Neuroscience to Therapy

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience
Cover of the book Programmed Cells from Basic Neuroscience to Therapy by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642366482
Publisher: Springer Berlin Heidelberg Publication: May 13, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783642366482
Publisher: Springer Berlin Heidelberg
Publication: May 13, 2013
Imprint: Springer
Language: English

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

More books from Springer Berlin Heidelberg

Cover of the book Citizenship and Migration in the Era of Globalization by
Cover of the book Animal Communication and Noise by
Cover of the book Spinal Cord Monitoring by
Cover of the book Uncertain Multi-Attribute Decision Making by
Cover of the book Advances in Elastomers I by
Cover of the book Verkettungsarten im Wertstrom schlanker Unternehmen by
Cover of the book The Histogenesis of the Spinal Ganglia by
Cover of the book Advanced Rubber Composites by
Cover of the book Climate Change and Water Resources by
Cover of the book Decision Tools for Radiation Oncology by
Cover of the book Grundrechte by
Cover of the book Yearbook of Intensive Care and Emergency Medicine 1997 by
Cover of the book Geology of the Northwest African Continental Margin by
Cover of the book Grundfragen der Medienwirtschaft by
Cover of the book Resource Curse or Cure ? by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy