Protein Complexes that Modify Chromatin

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics
Cover of the book Protein Complexes that Modify Chromatin by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642557477
Publisher: Springer Berlin Heidelberg Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9783642557477
Publisher: Springer Berlin Heidelberg
Publication: December 6, 2012
Imprint: Springer
Language: English

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten­ sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans­ acting factors. Our view of eukaryotic chromosomes has evolved dra­ matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi­ lize nucleosomes or stabilize nucleosomes. Awide variety of such com­ plexes have now been described. Some are abundant and may play glo­ bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten­ sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans­ acting factors. Our view of eukaryotic chromosomes has evolved dra­ matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi­ lize nucleosomes or stabilize nucleosomes. Awide variety of such com­ plexes have now been described. Some are abundant and may play glo­ bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

More books from Springer Berlin Heidelberg

Cover of the book Carbohydrates in Sustainable Development I by
Cover of the book Iatrogenic Carcinogenesis by
Cover of the book Electrophosphorescent Polymers Based on Polyarylether Hosts by
Cover of the book Fiber-Optic Transmission Networks by
Cover of the book The Rivers of Greece by
Cover of the book Inclusion Polymers by
Cover of the book The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes by
Cover of the book The Embryology of the Human Thyroid Gland Including Ultimobranchial Body and Others Related by
Cover of the book A Brief History of String Theory by
Cover of the book Field-Coupled Nanocomputing by
Cover of the book Glycoscience and Microbial Adhesion by
Cover of the book Staatssanierung durch Enteignung? by
Cover of the book Green China by
Cover of the book Eye Surgery by
Cover of the book Desertification by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy