Proteopathic Seeds and Neurodegenerative Diseases

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Specialties, Internal Medicine, Neuroscience, Science & Nature, Science
Cover of the book Proteopathic Seeds and Neurodegenerative Diseases by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642354915
Publisher: Springer Berlin Heidelberg Publication: March 27, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783642354915
Publisher: Springer Berlin Heidelberg
Publication: March 27, 2013
Imprint: Springer
Language: English

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

More books from Springer Berlin Heidelberg

Cover of the book Atlas of Pathological Computer Tomography by
Cover of the book Photovoltaik – Wie Sonne zu Strom wird by
Cover of the book Diabetes Mellitus: Pathophysiology and Therapy by
Cover of the book Elektrische Energieversorgung 1 by
Cover of the book Pediatric ENT Radiology by
Cover of the book The 19th International Conference on Industrial Engineering and Engineering Management by
Cover of the book Ecology and Evolution of the Freshwater Mussels Unionoida by
Cover of the book Design and Analysis of Materials and Engineering Structures by
Cover of the book Veranstaltungsmanagement by
Cover of the book Pflege deinen Humor by
Cover of the book Schumpeterian Perspectives on Innovation, Competition and Growth by
Cover of the book Volkswirtschaftslehre by
Cover of the book The Abel Prize 2008-2012 by
Cover of the book Competition and Coexistence by
Cover of the book Ionic Liquids for Better Separation Processes by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy