Purinergic Signalling and the Nervous System

Nonfiction, Health & Well Being, Medical, Medical Science, Physiology
Cover of the book Purinergic Signalling and the Nervous System by Geoffrey Burnstock, Verkhratsky Alexei, Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Geoffrey Burnstock, Verkhratsky Alexei ISBN: 9783642288630
Publisher: Springer Berlin Heidelberg Publication: June 5, 2012
Imprint: Springer Language: English
Author: Geoffrey Burnstock, Verkhratsky Alexei
ISBN: 9783642288630
Publisher: Springer Berlin Heidelberg
Publication: June 5, 2012
Imprint: Springer
Language: English

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

More books from Springer Berlin Heidelberg

Cover of the book The Glaucomas by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Kommentar zur Musterberufsordnung der deutschen Ärzte (MBO) by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Intestinal Absorptive Surface in Mammals of Different Sizes by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Surface Tension in Microsystems by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Contributions to the Psychobiology of Aging by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Nausea and Vomiting: Mechanisms and Treatment by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Design, Synthesis and Characterization of new Supramolecular Architectures by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Plant and Vegetation Mapping by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Basiswissen Allgemeinmedizin by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book So einfach ist Mathematik - Zwölf Herausforderungen im ersten Semester by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Sind Umweltkrisen Krisen der Natur oder der Kultur? by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Strategies of Multinational Corporations and Social Regulations by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Prehistoric Human Bone by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Environmental Photochemistry by Geoffrey Burnstock, Verkhratsky Alexei
Cover of the book Immunostimulatory DNA Sequences by Geoffrey Burnstock, Verkhratsky Alexei
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy